Target：PACR

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Circadian entrainment;Insulin secretion;Renin secretion

Gene Name：ADCYAP1R1

Protein Name：Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)

Human Gene Id：117

Human Swiss Prot No：P41586

Mouse Swiss Prot No：P70205

Rat Swiss Prot No：P32215

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：PACR Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：51kD

Background： This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010],

Function：function:This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.