Target：PABP5

Fields：mRNA surveillance pathway;RNA degradation

Gene Name：PABPC5

Protein Name：Polyadenylate-binding protein 5

Human Gene Id：140886

Human Swiss Prot No：Q96DU9

Immunogen：The antiserum was produced against synthesized peptide derived from human PABPC5. AA range:184-233

Specificity：PABP5 Polyclonal Antibody detects endogenous levels of PABP5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PABPC5;PABP5;Polyadenylate-binding protein 5;PABP-5;Poly(A)-binding protein 5

Observed Band(KD)：43kD

Background： This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010],

Function：function:Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.,similarity:Contains 4 RRM (RNA recognition motif) domains.,tissue specificity:Expressed in fetal brain and in a range of adult tissues.,

Subcellular Location：Cytoplasm .; [Isoform 2]: Mitochondrion matrix . Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

Expression：Expressed in fetal brain and in a range of adult tissues.