Target：PAR-3

Fields：Neuroactive ligand-receptor interaction;Complement and coagulation cascades

Gene Name：F2RL2

Protein Name：Proteinase-activated receptor 3

Human Gene Id：2151

Human Swiss Prot No：O00254

Mouse Swiss Prot No：O08675

Immunogen：The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87

Specificity：PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：F2RL2;PAR3;Proteinase-activated receptor 3;PAR-3;Coagulation factor II receptor-like 2;Thrombin receptor-like 2

Molecular Weight(Da)：43kD

Background： This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012],

Function：function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.