Target:PAR1
Fields:Rap1 signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;PI3K-Akt signaling pathway;Complement and coagulation cascades;Platelet activation;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Pathways in cancer
Gene Name:F2R CF2R PAR1 TR
Protein Name:Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Human Gene Id:2149
Human Swiss Prot No:P25116
Mouse Gene Id:14062
Mouse Swiss Prot No:P30558
Rat Swiss Prot No:P26824
Immunogen:Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal
Specificity:This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000, ELISA 1:10000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Observed Band(KD):46kD
Background: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
Function:function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Platelets and vascular endothelial cells.