Target：PAF-R

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction;Staphylococcus aureus infection

Gene Name：PTAFR

Protein Name：Platelet-activating factor receptor

Human Gene Id：5724

Human Swiss Prot No：P25105

Mouse Gene Id：19204

Mouse Swiss Prot No：Q62035

Rat Gene Id：58949

Rat Swiss Prot No：P46002

Immunogen：The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243

Specificity：PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTAFR;PAFR;Platelet-activating factor receptor;PAF-R;PAFr

Molecular Weight(Da)：39kD

Background： This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Function：function:Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.,induction:By granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.