Target：PDE4C
Fields：Purine metabolism;Metabolic pathways;cAMP signaling pathway;Parathyroid hormone synthesis, secretion and action;Morphine addiction
Gene Name：PDE4C
Protein Name：cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Human Gene Id：5143
Human Swiss Prot No：Q08493
Mouse Gene Id：110385
Mouse Swiss Prot No：Q3UEI1
Rat Swiss Prot No：P14644
Immunogen：The antiserum was produced against synthesized peptide derived from human PDE4C. AA range:291-340
Specificity：PDE4C Polyclonal Antibody detects endogenous levels of PDE4C protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PDE4C;DPDE1;cAMP-specific 3';5'-cyclic phosphodiesterase 4C;DPDE1;PDE21
Observed Band(KD)：80kD
Background： The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
Function：catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in various tissues but not in cells of the immune system.,
Subcellular Location：Cell projection, cilium .
Expression：Expressed in various tissues but not in cells of the immune system.
