Target：PCBP2

Fields：Ferroptosis

Gene Name：PCBP2

Protein Name：Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)

Human Gene Id：5094

Human Swiss Prot No：Q15366

Mouse Swiss Prot No：Q61990

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：PCBP2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：40kD

Background： The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate

Function：function:Major cellular poly(rC)-binding protein. Binds also poly(rU).,PTM:Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.,similarity:Contains 3 KH domains.,subcellular location:Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.,tissue specificity:Detected in all tissues examined.,

Subcellular Location：Nucleus . Cytoplasm . Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Expression：Detected in all tissues examined.