Target：PBR

Fields：Neuroactive ligand-receptor interaction;Cholesterol metabolism;Human T-cell leukemia virus 1 infection

Gene Name：TSPO

Protein Name：Translocator protein

Human Gene Id：706

Human Swiss Prot No：P30536

Immunogen：Synthesized peptide derived from PBR . at AA range: 90-170

Specificity：PBR Polyclonal Antibody detects endogenous levels of PBR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TSPO;BZRP;MBR;Translocator protein;Mitochondrial benzodiazepine receptor;PKBS;Peripheral-type benzodiazepine receptor;PBR

Observed Band(KD)：20kD

Background： Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012],

Function：protein targeting, protein targeting to mitochondrion, porphyrin metabolic process, porphyrin biosynthetic process,heme biosynthetic process, ion transport, anion transport, mitochondrial transport, intracellular protein transport,apoptosis, mitochondrion organization, protein localization, steroid metabolic process, cell death, cell proliferation,programmed cell death, protein transport, death, protein import, heterocycle biosynthetic process, regulation of lipid transport, regulation of sterol transport, regulation of cholesterol transport, tetrapyrrole metabolic process,tetrapyrrole biosynthetic process, protein localization in organelle, cellular protein localization, heme metabolic process, pigment metabolic process, nitrogen compound biosynthetic process, establishment of protein localization,pigment biosynthetic process, intracellular transport, cofactor metabolic process, cofacto

Subcellular Location：Mitochondrion membrane ; Multi-pass membrane protein .

Expression：Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.