Target：PF-4
Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Chemokine signaling pathway
Gene Name：PF4 CXCL4 SCYB4
Protein Name：Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
Human Gene Id：5196
Human Swiss Prot No：P02776
Mouse Gene Id：56744
Mouse Swiss Prot No：Q9Z126
Rat Swiss Prot No：P06765
Immunogen：Synthetic peptide from human protein at AA range: 51-100
Specificity：The antibody detects endogenous PF-4
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Platelet factor 4 (PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
Molecular Weight(Da)：11kD
Background： This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014],
Function：function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.,mass spectrometry: PubMed:7644496,mass spectrometry:Short form PubMed:7644496,online information:CXCL4 entry,PTM:Binds non-covalently to a proteoglycan molecule.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homotetramer.,
Subcellular Location：Secreted .
Expression： Leukocyte,
