Target：PEAR1

Gene Name：PEAR1 MEGF12

Protein Name：Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)

Human Gene Id：375033

Human Swiss Prot No：Q5VY43

Mouse Swiss Prot No：Q8VIK5

Immunogen：Synthesized peptide derived from human protein . at AA range: 910-990

Specificity：PEAR1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：114kD

Background： PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008],

Function：function:When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.,PTM:Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.,similarity:Belongs to the MEGF family.,similarity:Contains 1 EMI domain.,similarity:Contains 9 EGF-like domains.,subcellular location:Detected on the cell surface in resting platelets.,subunit:Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.,tissue specificity:Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas

Subcellular Location：Cell membrane ; Single-pass membrane protein . Detected on the cell surface in resting platelets. .

Expression：Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.