Target：PDK2

Fields：Diabetic cardiomyopathy

Gene Name：PDK2

Protein Name：[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 mitochondrial

Human Gene Id：5164

Human Swiss Prot No：Q15119

Mouse Gene Id：18604

Mouse Swiss Prot No：Q9JK42

Rat Gene Id：81530

Rat Swiss Prot No：Q64536

Immunogen：The antiserum was produced against synthesized peptide derived from human PDK2. AA range:260-309

Specificity：PDK2 Polyclonal Antibody detects endogenous levels of PDK2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PDK2;PDHK2;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial;Pyruvate dehydrogenase kinase isoform 2

Observed Band(KD)：46kD

Background： This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Function：catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.,

Subcellular Location：Mitochondrion matrix.

Expression：Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.