Target:Fucokinase
Fields:Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of nucleotide sugars
Gene Name:FUK
Protein Name:L-fucose kinase
Human Gene Id:197258
Human Swiss Prot No:Q8N0W3
Immunogen:The antiserum was produced against synthesized peptide derived from human FUK. AA range:11-60
Specificity:Fucokinase Polyclonal Antibody detects endogenous levels of Fucokinase protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:FUK;L-fucose kinase;Fucokinase
Observed Band(KD):110kD
Background:fucokinase(FUK) Homo sapiens The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008],
Function:catalytic activity:ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.,function:Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.,similarity:Belongs to the GHMP kinase family.,
Subcellular Location:cytoplasm,cytosol,
Expression:Expressed in fibroblasts.