Target：FRS3

Gene Name：FRS3

Protein Name：Fibroblast growth factor receptor substrate 3

Human Gene Id：10817

Human Swiss Prot No：O43559

Mouse Swiss Prot No：Q91WJ0

Immunogen：The antiserum was produced against synthesized peptide derived from human FRS3. AA range:191-240

Specificity：FRS3 Polyclonal Antibody detects endogenous levels of FRS3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FRS3;Fibroblast growth factor receptor substrate 3;FGFR substrate 3;FGFR-signaling adaptor SNT2;Suc1-associated neurotrophic factor target 2;SNT-2

Observed Band(KD)：54kD

Background： This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013],

Function：function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.,PTM:Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.,similarity:Contains 1 IRS-type PTB domain.,subunit:Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.,

Subcellular Location：Membrane; Lipid-anchor.

Expression： Brain,Placenta,