Target：PIF1

Gene Name：PIF1 C15orf20

Protein Name：ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (PIF1/RRM3 DNA helicase-like protein)

Human Gene Id：80119

Human Swiss Prot No：Q9H611

Mouse Swiss Prot No：Q80SX8

Rat Swiss Prot No：Q1HG60

Immunogen：Synthesized peptide derived from human protein . at AA range: 150-230

Specificity：PIF1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：70kD

Background： This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013],

Function：function:DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase.,similarity:Belongs to the helicase family.,subunit:Interacts with telomerase.,tissue specificity:Weak ubiquitous expression.,

Subcellular Location：Nucleus .; [Isoform 4]: Mitochondrion .

Expression：Weak ubiquitous expression.