Target：PI3R6

Fields：cGMP-PKG signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Adrenergic signaling in cardiomyocytes;Apelin signaling pathway;Platelet activation;Cholinergic synapse;Oxytocin signaling pathway;Toxoplasmosis;Kaposi sarcoma-associated herpesvirus infection

Gene Name：PIK3R6 C17orf38

Protein Name：Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)

Human Gene Id：146850

Human Swiss Prot No：Q5UE93

Mouse Swiss Prot No：Q3U6Q4

Immunogen：Synthesized peptide derived from human protein . at AA range: 280-360

Specificity：PI3R6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：82kD

Background： Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Function：function:Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by G beta gamma proteins.,subunit:Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. Also interacts with PDE3B and G beta gamma proteins. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG.,

Subcellular Location：Cytoplasm . Cell membrane ; Peripheral membrane protein . Translocated to the plasma membrane in a Ras-dependent manner. .

Expression： Stomach,