Target：PI 3-Kinase C2γ

Fields：Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Salmonella infection

Gene Name：PIK3C2G

Protein Name：Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Human Gene Id：5288

Human Swiss Prot No：O75747

Mouse Swiss Prot No：O70167

Immunogen：Synthesized peptide derived from the N-terminal region of human PI 3-Kinase C2γ.

Specificity：PI 3-Kinase C2γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase C2γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PIK3C2G;Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma;PI3K-C2-gamma;PtdIns-3-kinase C2 subunit gamma;Phosphoinositide 3-kinase-C2-gamma

Observed Band(KD)：160kD

Background： The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Function：catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.,function:In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 1 PX (phox homology) domain.,tissue specificity:Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.,

Subcellular Location：Membrane ; Peripheral membrane protein .

Expression：Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.