Target：PSF2

Gene Name：GINS2 PSF2 CGI-122 DC5 HSPC037

Protein Name：DNA replication complex GINS protein PSF2 (GINS complex subunit 2)

Human Gene Id：51659

Human Swiss Prot No：Q9Y248

Mouse Swiss Prot No：Q9D600

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PSF2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：20kD

Background： The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008],

Function：function:The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.,mass spectrometry:This is the measured mass for the GINS complex PubMed:17557111,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the GINS2/PSF2 family.,subunit:Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.,

Subcellular Location：Nucleus . Chromosome . Associates with chromatin. .

Expression： Brain,Dendritic cell,Umbilical cord blood,