Target:PSD4
Fields:Endocytosis
Gene Name:PSD4 EFA6B TIC
Protein Name:PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein
Human Gene Id:23550
Human Swiss Prot No:Q8NDX1
Mouse Swiss Prot No:Q8BLR5
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:PSD4 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):116kD
Background:function:Guanine nucleotide exchange factor for ARF6-like protein. Involved in membrane recycling.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures.,tissue specificity:Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.,
Function:function:Guanine nucleotide exchange factor for ARF6-like protein. Involved in membrane recycling.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures.,tissue specificity:Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.,
Subcellular Location:Cell membrane . Cell projection, ruffle membrane . In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable). .
Expression:Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.