Target:PRPF18
Fields:Spliceosome
Gene Name:PRPF18
Protein Name:Pre-mRNA-splicing factor 18
Human Gene Id:8559
Human Swiss Prot No:Q99633
Mouse Gene Id:67229
Mouse Swiss Prot No:Q8BM39
Rat Gene Id:171552
Rat Swiss Prot No:Q9JKB8
Immunogen:The antiserum was produced against synthesized peptide derived from human PRPF18. AA range:182-231
Specificity:PRPF18 Polyclonal Antibody detects endogenous levels of PRPF18 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PRPF18;HPRP18;Pre-mRNA-splicing factor 18;PRP18 homolog;hPRP18
Observed Band(KD):40kD
Background: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008],
Function:function:Participates in the second step of pre-mRNA splicing.,similarity:Belongs to the PRP18 family.,subcellular location:Colocalizes with spliceosomal snRNPs.,subunit:Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.,
Subcellular Location:Nucleus speckle . Colocalizes with spliceosomal snRNPs. .
Expression: Brain,Cervix carcinoma,Placenta,