Target：PRLR

Fields：Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;PI3K-Akt signaling pathway;JAK-STAT signaling pathway;Prolactin signaling pathway

Gene Name：PRLR

Protein Name：Prolactin receptor (PRL-R)

Human Gene Id：5618

Human Swiss Prot No：P16471

Mouse Swiss Prot No：Q08501

Rat Swiss Prot No：P05710

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：PRLR Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：68kD

Background： This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],

Function：domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.

Expression：Expressed in breast, placenta, kidney, liver and pancreas.