Target：PRKX

Gene Name：PRKX

Protein Name：cAMP-dependent protein kinase catalytic subunit PRKX

Human Gene Id：5613

Human Swiss Prot No：P51817

Mouse Gene Id：19108

Mouse Swiss Prot No：Q922R0

Immunogen：The antiserum was produced against synthesized peptide derived from human PRKX. AA range:251-300

Specificity：PRKX Polyclonal Antibody detects endogenous levels of PRKX protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PRKX;PKX1;cAMP-dependent protein kinase catalytic subunit PRKX;PrKX;Protein kinase X;Protein kinase X-linked;Serine/threonine-protein kinase PRKX;Protein kinase PKX1

Observed Band(KD)：41kD

Background： This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:High levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.,

Subcellular Location：Cytoplasm. Nucleus. cAMP induces nuclear translocation.

Expression：Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.