Target：PPP2R3C

Fields：mRNA surveillance pathway;Sphingolipid signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Adrenergic signaling in cardiomyocytes;Dopaminergic synapse;Human papillomavirus infection

Gene Name：PPP2R3C

Protein Name：Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Human Gene Id：55012

Human Swiss Prot No：Q969Q6

Mouse Gene Id：59032

Mouse Swiss Prot No：Q9JK24

Rat Gene Id：362739

Rat Swiss Prot No：Q6AXZ3

Immunogen：The antiserum was produced against synthesized peptide derived from human PPP2R3C. AA range:165-214

Specificity：PPP2R3C Polyclonal Antibody detects endogenous levels of PPP2R3C protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPP2R3C;C14orf10;G5PR;Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma;Protein phosphatase subunit G5PR;Rhabdomyosarcoma antigen MU-RMS-40.6A/6C

Observed Band(KD)：55kD

Background： This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],

Function：developmental stage:Expressed in fetal brain.,function:May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells.,similarity:Contains 2 EF-hand domains.,subcellular location:Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.,subunit:Interacts with MCM3AP/GANP (By similarity). Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.,tissue specificity:Ubiquitously expressed in brain and other tissues.,

Subcellular Location：Nucleus . Cytoplasm . Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. .

Expression：Ubiquitously expressed in brain and other tissues.