Target：PPM1E

Gene Name：PPM1E CAMKN KIAA1072 POPX1

Protein Name：Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)

Human Swiss Prot No：Q8WY54

Mouse Swiss Prot No：Q80TL0

Rat Swiss Prot No：Q80Z30

Immunogen：Synthesized peptide derived from human protein . at AA range: 460-540

Specificity：PPM1E Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：84kD

Background： This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012],

Function：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subcellular location:A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus.,subunit:Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).,

Subcellular Location：Nucleus . Cytoplasm . A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. .

Expression： Brain,Testis,