Target:RGS1
Gene Name:RGS1
Protein Name:Regulator of G-protein signaling 1
Human Gene Id:5996
Human Swiss Prot No:Q08116
Mouse Gene Id:50778
Mouse Swiss Prot No:Q9JL25
Rat Gene Id:54289
Rat Swiss Prot No:P97844
Immunogen:The antiserum was produced against synthesized peptide derived from human RGS1. AA range:118-167
Specificity:RGS1 Polyclonal Antibody detects endogenous levels of RGS1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:RGS1;1R20;BL34;IER1;Regulator of G-protein signaling 1;RGS1;B-cell activation protein BL34;Early response protein 1R20
Observed Band(KD):22kD
Background: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008],
Function:function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.,induction:In response to several B-cell activation signals.,PTM:Could be phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Contains 1 RGS domain.,tissue specificity:B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin's lymphoma and hairy cell leukemia, expression is constitutively high.,
Subcellular Location:Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
Expression:Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).