Target：Frizzled-9

Fields：mTOR signaling pathway;Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Melanogenesis;Cushing syndrome;Alzheimer disease;Pathways of neurodegeneration - multiple diseases;Human papillomavirus infection;Pathways in cancer;Proteoglycans in cancer;Basal cell carcinoma;Breast cancer;Hepatocellular carcinoma;Gastric cancer

Gene Name：FZD9

Protein Name：Frizzled-9

Human Gene Id：8326

Human Swiss Prot No：O00144

Mouse Gene Id：14371

Mouse Swiss Prot No：Q9R216

Immunogen：The antiserum was produced against synthesized peptide derived from human FZD9. AA range:542-591

Specificity：Frizzled-9 Polyclonal Antibody detects endogenous levels of Frizzled-9 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FZD9;FZD3;Frizzled-9;Fz-9;hFz9;FzE6;CD antigen CD349

Observed Band(KD)：64kD

Background：frizzled class receptor 9(FZD9) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008],

Function：caution:Has been first described as FZD3 in litterature.,domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular t

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. .

Expression：Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850).