Target：PTPζ

Fields：Epithelial cell signaling in Helicobacter pylori infection

Gene Name：PTPRZ1

Protein Name：Receptor-type tyrosine-protein phosphatase zeta

Human Gene Id：5803

Human Swiss Prot No：P23471

Rat Gene Id：25613

Rat Swiss Prot No：Q62656

Immunogen：The antiserum was produced against synthesized peptide derived from human PTPRZ1. AA range:122-171

Specificity：PTPζ Polyclonal Antibody detects endogenous levels of PTPζ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTPRZ1;HTPZP2;PTPRZ;PTPRZ2;PTPZ;Receptor-type tyrosine-protein phosphatase zeta;R-PTP-zeta;Protein-tyrosine phosphatase receptor type Z polypeptide 1;Protein-tyrosine phosphatase receptor type Z polypeptide 2;R-PTP-zeta-2

Observed Band(KD)：250kD

Background： This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011],

Function：catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,caution:PubMed:8387522 and PubMed:2170109 have termed this protein RPTPase beta.,function:May be involved in the regulation of specific developmental processes in the CNS.,sequence caution:Contaminating sequence. The N-terminus may be contaminated with vector sequence.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.,similarity:Contains 1 alpha-carbonic anhydrase domain.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,subunit:The carbonic-anhydrase like domain binds to contactin.,tissue specificity:Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral v

Subcellular Location：[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted . A secreted form is apparently generated by shedding of the extracellular domain. .; [Isoform 2]: Secreted .

Expression：Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.