Target：RACK7

Gene Name：ZMYND8

Protein Name：Protein kinase C-binding protein 1

Human Gene Id：23613

Human Swiss Prot No：Q9ULU4

Immunogen：The antiserum was produced against synthesized peptide derived from human PKCB1. AA range:581-630

Specificity：RACK7 Polyclonal Antibody detects endogenous levels of RACK7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ZMYND8;KIAA1125;PRKCBP1;RACK7;Protein kinase C-binding protein 1;Cutaneous T-cell lymphoma-associated antigen se14-3;CTCL-associated antigen se14-3;Rack7;Zinc finger MYND domain-containing protein 8

Observed Band(KD)：132kD

Background： The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 bromo domain.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 PWWP domain.,subunit:Interacts in vitro with PRKCB1.,tissue specificity:Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).,

Subcellular Location：Nucleus . Cytoplasm . Sequestered in the cytoplasm through the interaction with DBN1. .

Expression：Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).