Target：RASSF2

Fields：Hippo signaling pathway - multiple species

Gene Name：RASSF2

Protein Name：Ras association domain-containing protein 2

Human Gene Id：9770

Human Swiss Prot No：P50749

Mouse Gene Id：215653

Mouse Swiss Prot No：Q8BMS9

Rat Gene Id：311437

Rat Swiss Prot No：Q3B7D5

Immunogen：The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158

Specificity：RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RASSF2;KIAA0168;Ras association domain-containing protein 2

Observed Band(KD)：36kD

Background： This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008],

Function：function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.,

Subcellular Location：Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Expression：Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.