Target：RASA2

Fields：MAPK signaling pathway;Ras signaling pathway;Viral carcinogenesis

Gene Name：RASA2 GAP1M RASGAP

Protein Name：Ras GTPase-activating protein 2 (GAP1m)

Human Gene Id：5922

Human Swiss Prot No：Q15283

Mouse Swiss Prot No：P58069

Rat Swiss Prot No：Q63713

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：RASA2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：93kD

Background： The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Function：function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,

Subcellular Location：Cytoplasm. Cytoplasm, perinuclear region.

Expression： Blood,Brain,