Target：RAP1

Gene Name：TERF2IP

Protein Name：Telomeric repeat-binding factor 2-interacting protein 1

Human Gene Id：54386

Human Swiss Prot No：Q9NYB0

Mouse Swiss Prot No：Q91VL8

Immunogen：The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252

Specificity：RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TERF2IP;DRIP5;RAP1;PP8000;Telomeric repeat-binding factor 2-interacting protein 1;TERF2-interacting telomeric protein 1;TRF2-interacting telomeric protein 1;Dopamine receptor-interacting protein 5;Repressor/activator protein 1 homol

Observed Band(KD)：55kD

Background： The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],

Function：function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TE

Subcellular Location：Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .

Expression：Ubiquitous. Highly expressed.