Target：Rak

Gene Name：FRK

Protein Name：Tyrosine-protein kinase FRK

Human Gene Id：2444

Human Swiss Prot No：P42685

Mouse Gene Id：14302

Mouse Swiss Prot No：Q922K9

Rat Gene Id：79209

Rat Swiss Prot No：Q62662

Immunogen：The antiserum was produced against synthesized peptide derived from human FRK. AA range:71-120

Specificity：Rak Polyclonal Antibody detects endogenous levels of Rak protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FRK;PTK5;RAK;Tyrosine-protein kinase FRK;FYN-related kinase;Nuclear tyrosine protein kinase RAK;Protein-tyrosine kinase 5

Observed Band(KD)：55kD

Background： The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin.,

Subcellular Location：Cytoplasm . Nucleus . Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Expression：Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.