Target：Rag B

Fields：Autophagy - animal;mTOR signaling pathway;Shigellosis

Gene Name：RRAGB

Protein Name：Ras-related GTP-binding protein B

Human Gene Id：10325

Human Swiss Prot No：Q5VZM2

Mouse Gene Id：245670

Mouse Swiss Prot No：Q6NTA4

Rat Gene Id：1.0091e+008

Rat Swiss Prot No：Q63487

Immunogen：Synthesized peptide derived from Rag B . at AA range: 50-130

Specificity：Rag B Polyclonal Antibody detects endogenous levels of Rag B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RRAGB;Ras-related GTP-binding protein B;Rag B;RagB

Molecular Weight(Da)：43kD

Background： Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：function:Involved in the RCC1/Ran-GTPase pathway. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subunit:The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD.,

Subcellular Location：Cytoplasm . Lysosome .

Expression： Adipose tissue,Brain,Skin,