Target:TALK-2
Gene Name:KCNK17
Protein Name:Potassium channel subfamily K member 17
Human Gene Id:89822
Human Swiss Prot No:Q96T54
Immunogen:The antiserum was produced against synthesized peptide derived from human KCNK17. AA range:271-320
Specificity:TALK-2 Polyclonal Antibody detects endogenous levels of TALK-2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:KCNK17;TALK2;TASK4;Potassium channel subfamily K member 17;2P domain potassium channel Talk-2;Acid-sensitive potassium channel protein TASK-4;TWIK-related acid-sensitive K(+) channel 4;TWIK-related alkaline pH-activated K(+) channel
Observed Band(KD):37-42kD
Background:potassium two pore domain channel subfamily K member 17(KCNK17) Homo sapiens The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
Function:function:Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.,miscellaneous:Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,
Subcellular Location:Membrane; Multi-pass membrane protein.
Expression: Adrenal gland,Lung,Pancreas,Spleen,