Target:TAFI
Fields:Complement and coagulation cascades;Pancreatic secretion;Protein digestion and absorption
Gene Name:CPB2
Protein Name:Carboxypeptidase B2
Human Gene Id:1361
Human Swiss Prot No:Q96IY4
Mouse Swiss Prot No:Q9JHH6
Immunogen:The antiserum was produced against synthesized peptide derived from human CPB2. AA range:321-370
Specificity:TAFI Polyclonal Antibody detects endogenous levels of TAFI protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:CPB2;Carboxypeptidase B2;Carboxypeptidase U;CPU;Plasma carboxypeptidase B;pCPB;Thrombin-activable fibrinolysis inhibitor;TAFI
Observed Band(KD):48kD
Background: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Function:catalytic activity:Release of C-terminal Arg and Lys from a polypeptide.,cofactor:Binds 1 zinc ion per subunit.,function:Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Plasma; synthesized in the liver.,
Subcellular Location:Secreted.
Expression:Plasma; synthesized in the liver.