Target：TEF-1

Fields：Hippo signaling pathway;Hippo signaling pathway - multiple species

Gene Name：TEAD1

Protein Name：Transcriptional enhancer factor TEF-1

Human Gene Id：7003

Human Swiss Prot No：P28347

Mouse Gene Id：21676

Mouse Swiss Prot No：P30051

Immunogen：Synthesized peptide derived from TEF-1 . at AA range: 30-110

Specificity：TEF-1 Polyclonal Antibody detects endogenous levels of TEF-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TEAD1;TCF13;TEF1;Transcriptional enhancer factor TEF-1;NTEF-1;Protein GT-IIC;TEA domain family member 1;TEAD-1;Transcription factor 13;TCF-13

Observed Band(KD)：50kD

Background： This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010],

Function：disease:Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.,function:Binds specifically and cooperatively to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.,similarity:Contains 1 TEA DNA-binding domain.,tissue specificity:Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.,

Subcellular Location：Nucleus.

Expression：Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.