Target:TDAG51
Gene Name:PHLDA1
Protein Name:Pleckstrin homology-like domain family A member 1
Human Gene Id:22822
Human Swiss Prot No:Q8WV24
Mouse Gene Id:21664
Mouse Swiss Prot No:Q62392
Rat Swiss Prot No:Q9QZA1
Immunogen:The antiserum was produced against synthesized peptide derived from human PHLA1. AA range:271-320
Specificity:TDAG51 Polyclonal Antibody detects endogenous levels of TDAG51 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PHLDA1;PHRIP;TDAG51;Pleckstrin homology-like domain family A member 1;Apoptosis-associated nuclear protein;Proline- and glutamine-rich protein;PQ-rich protein;PQR protein;Proline- and histidine-rich protein;T-cell death-associated
Observed Band(KD):40kD
Background: This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008],
Function:function:Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.,induction:Induced by homocysteine and other ER stress-inducing reagents. Induced by phorbolester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.,similarity:Contains 1 PH domain.,subcellular location:Colocalizes with intracellular vesicles.,subunit:Interacts with RPL14, EIF3S7 and PABPC4.,tissue specificity:Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).,
Subcellular Location:Cytoplasm . Cytoplasmic vesicle . Nucleus, nucleolus . Colocalizes with intracellular vesicles. .
Expression:Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).