Target：TCEAL1

Gene Name：TCEAL1

Protein Name：Transcription elongation factor A protein-like 1

Human Gene Id：9338

Human Swiss Prot No：Q15170

Mouse Gene Id：237052

Mouse Swiss Prot No：Q921P9

Rat Gene Id：302593

Rat Swiss Prot No：Q5PPP3

Immunogen：The antiserum was produced against synthesized peptide derived from human TCEAL1. AA range:91-140

Specificity：TCEAL1 Polyclonal Antibody detects endogenous levels of TCEAL1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TCEAL1;SIIR;Transcription elongation factor A protein-like 1;TCEA-like protein 1;Nuclear phosphoprotein p21/SIIR;Transcription elongation factor S-II protein-like 1

Observed Band(KD)：20kD

Background： This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008],

Function：function:May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.,PTM:Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.,similarity:Belongs to the TFS-II family. TFA subfamily.,tissue specificity:Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.,

Subcellular Location：Nucleus.

Expression：Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.