Target：TBX2/3
Fields：Signaling pathways regulating pluripotency of stem cells
Gene Name：TBX2/TBX3
Protein Name：T-box transcription factor TBX2/3
Human Gene Id：6926
Human Swiss Prot No：O15119/Q13207
Mouse Gene Id：21386/21385
Rat Gene Id：353305
Rat Swiss Prot No：Q7TST9
Immunogen：The antiserum was produced against synthesized peptide derived from human TBX3. AA range:271-320
Specificity：TBX2/3 Polyclonal Antibody detects endogenous levels of TBX2/3 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TBX3;T-box transcription factor TBX3;T-box protein 3;TBX2;T-box transcription factor TBX2;T-box protein 2
Observed Band(KD)：79kD
Background： This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
Function：disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,
Subcellular Location：Nucleus .
Expression：Widely expressed.
