Target：TGFβ2
Fields：MAPK signaling pathway;Cytokine-cytokine receptor interaction;FoxO signaling pathway;Cell cycle;Cellular senescence;TGF-beta signaling pathway;Osteoclast differentiation;Hippo signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Leishmaniasis;Chagas disease;Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Hepatitis B;Human T-cell leukemia virus 1 infection;Pathways in cancer;Proteoglycans in cancer;MicroRNAs in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leukemia;Hepatocellular carcinoma;Gastric cancer;Inflammatory bowel disease;Rheumatoid arthritis;Hypertrophic cardiomyopathy;Dilated cardiomyopathy;Diabetic cardiomyopathy
Gene Name：TGFB2
Protein Name：Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin)
Human Gene Id：7042
Human Swiss Prot No：P61812
Mouse Gene Id：21808
Mouse Swiss Prot No：P27090
Rat Swiss Prot No：Q07257
Immunogen：The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410
Specificity：The antibody detects endogenous TGFβ2
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Transforming growth factor beta-2 (TGF-beta-2;BSC-1 cell growth inhibitor;Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;Polyergin)
Observed Band(KD)：47kD,12kD
Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the an
Function：disease:A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with HDAC9. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.,function:TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.,online information:TGF beta-2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Subcellular Location：[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-2]: Secreted .
Expression： Aorta endothelial cell,Lung,
