Target：TGase2

Fields：Huntington disease

Gene Name：TGM2

Protein Name：Protein-glutamine gamma-glutamyltransferase 2

Human Gene Id：7052

Human Swiss Prot No：P21980

Mouse Gene Id：21817

Mouse Swiss Prot No：P21981

Immunogen：The antiserum was produced against synthesized peptide derived from human Transglutaminase 2. AA range:1-50

Specificity：TGase2 Polyclonal Antibody detects endogenous levels of TGase2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TGM2;Protein-glutamine gamma-glutamyltransferase 2;Tissue transglutaminase;Transglutaminase C;TG(C);TGC;TGase C;Transglutaminase H;TGase H;Transglutaminase-2;TGase-2

Observed Band(KD)：90kD

Background： Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in TGM2 are involved in early-onset diabetes type 2.,function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer.,

Subcellular Location：Cytoplasm, cytosol . Nucleus . Chromosome . Secreted, extracellular space, extracellular matrix . Cell membrane . Mitochondrion . Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). .; [Isoform 2]: Cytoplasm, perinuclear region .

Expression： Brain,Colon adenocarcinoma,Endothelial cell,Kidney,Liver,Lymph node,Ovarian carcino