Target：TIMP-4

Gene Name：TIMP4

Protein Name：Metalloproteinase inhibitor 4

Human Gene Id：7079

Human Swiss Prot No：Q99727

Mouse Gene Id：110595

Mouse Swiss Prot No：Q9JHB3

Rat Gene Id：680130

Rat Swiss Prot No：P81556

Immunogen：The antiserum was produced against synthesized peptide derived from human TIMP4. AA range:175-224

Specificity：TIMP-4 Polyclonal Antibody detects endogenous levels of TIMP-4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TIMP4;Metalloproteinase inhibitor 4;Tissue inhibitor of metalloproteinases 4;TIMP-4

Observed Band(KD)：26kD

Background： This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008],

Function：function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,tissue specificity:Abundant in heart and present at low levels in many other tissues.,

Subcellular Location：Secreted.

Expression：Abundant in heart and present at low levels in many other tissues.