Target：Tie-1
Gene Name：TIE1
Protein Name：Tyrosine-protein kinase receptor Tie-1
Human Gene Id：7075
Human Swiss Prot No：P35590
Mouse Gene Id：21846
Mouse Swiss Prot No：Q06806
Immunogen：The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900
Specificity：Tie-1 Polyclonal Antibody detects endogenous levels of Tie-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TIE1;TIE;Tyrosine-protein kinase receptor Tie-1
Observed Band(KD)：130kD
Background： This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Probable protein tyrosine-kinase transmembrane receptor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:Specifically expressed in developing vascular endothelial cells.,
Subcellular Location：Cell membrane ; Single-pass type I membrane protein .
Expression：Specifically expressed in developing vascular endothelial cells.
