Target：TNR8
Fields：Cytokine-cytokine receptor interaction
Gene Name：TNFRSF8 CD30 D1S166E
Protein Name：Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
Human Gene Id：943
Human Swiss Prot No：P28908
Mouse Swiss Prot No：Q60846
Rat Swiss Prot No：P97525
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：TNR8 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 IHC: 50-200 ELISA 1:5000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：65kD
Background： The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
Function：disease:Most specific Hodgkin disease associated antigen.,function:Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Contains 6 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.,
Subcellular Location：[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cytoplasm .
Expression：[Isoform 2]: Detected in alveolar macrophages (at protein level).
