Target：TNR19

Fields：Cytokine-cytokine receptor interaction

Gene Name：TNFRSF19 TAJ TROY UNQ1888/PRO4333

Protein Name：Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)

Human Gene Id：55504

Human Swiss Prot No：Q9NS68

Mouse Swiss Prot No：Q9JLL3

Immunogen：Synthesized peptide derived from human protein . at AA range: 20-100

Specificity：TNR19 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：46kD

Background： The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],

Function：function:Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.,tissue specificity:Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.,

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.