Target：TNIK

Gene Name：TNIK KIAA0551

Protein Name：TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)

Human Gene Id：23043

Human Swiss Prot No：Q9UKE5

Mouse Swiss Prot No：P83510

Immunogen：Synthesized peptide derived from human protein . at AA range: 350-430

Specificity：TNIK Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：149kD

Background： Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TRAF2 and NCK.,tissue specificity:Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle.,

Subcellular Location：Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Expression：Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.