Target:TNF-IP 8L2
Gene Name:TNFAIP8L2
Protein Name:Tumor necrosis factor alpha-induced protein 8-like protein 2
Human Gene Id:79626
Human Swiss Prot No:Q6P589
Mouse Gene Id:69769
Mouse Swiss Prot No:Q9D8Y7
Rat Gene Id:310663
Rat Swiss Prot No:Q6AYJ8
Immunogen:The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60
Specificity:TNF-IP 8L2 Polyclonal Antibody detects endogenous levels of TNF-IP 8L2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TNFAIP8L2;Tumor necrosis factor alpha-induced protein 8-like protein 2;TIPE2;TNF alpha-induced protein 8-like protein 2;TNFAIP8-like protein 2;Inflammation factor protein 20
Observed Band(KD):20kD
Background:domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,
Function:domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,
Subcellular Location:cytoplasm,
Expression: Lymph node,Pancreas,Small intestine,