Target:UTP14A
Fields:Ribosome biogenesis in eukaryotes
Gene Name:UTP14A
Protein Name:U3 small nucleolar RNA-associated protein 14 homolog A
Human Gene Id:10813
Human Swiss Prot No:Q9BVJ6
Mouse Gene Id:72554
Mouse Swiss Prot No:Q640M1
Immunogen:The antiserum was produced against synthesized peptide derived from human UTP14A. AA range:321-370
Specificity:UTP14A Polyclonal Antibody detects endogenous levels of UTP14A protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:UTP14A;SDCCAG16;U3 small nucleolar RNA-associated protein 14 homolog A;Antigen NY-CO-16;Serologically defined colon cancer antigen 16
Observed Band(KD):85kD
Background: This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
Function:function:May be required for ribosome biogenesis.,miscellaneous:The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UTP14 family.,tissue specificity:Ubiquitously expressed.,
Subcellular Location:Nucleus, nucleolus .
Expression:Ubiquitously expressed.