Target：USP48

Gene Name：USP48

Protein Name：Ubiquitin carboxyl-terminal hydrolase 48

Human Gene Id：84196

Human Swiss Prot No：Q86UV5

Mouse Gene Id：170707

Mouse Swiss Prot No：Q3V0C5

Rat Gene Id：362636

Rat Swiss Prot No：Q76LT8

Immunogen：The antiserum was produced against synthesized peptide derived from human USP48. AA range:631-680

Specificity：USP48 Polyclonal Antibody detects endogenous levels of USP48 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：USP48;USP31;Ubiquitin carboxyl-terminal hydrolase 48;Deubiquitinating enzyme 48;Ubiquitin thioesterase 48;Ubiquitin-specific-processing protease 48

Observed Band(KD)：120kD

Background： This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:Was named USP31 by some authors (PubMed:15354349 and PubMed:17081983).,function:Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 3 DUSP domains.,subunit:Interacts with TRAF2 and RELA.,tissue specificity:Widely expressed.,

Subcellular Location：Cytoplasm . Nucleus .

Expression：Widely expressed.