Target：UBXN4

Fields：Protein processing in endoplasmic reticulum

Gene Name：UBXN4 KIAA0242 UBXD2 UBXDC1

Protein Name：UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)

Human Gene Id：23190

Human Swiss Prot No：Q92575

Mouse Swiss Prot No：Q8VCH8

Rat Swiss Prot No：Q5HZY0

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：UBXN4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background： UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008],

Function：domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,

Subcellular Location：Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. .

Expression：Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).