Target：REV1

Fields：Fanconi anemia pathway

Gene Name：REV1 REV1L

Protein Name：DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase)

Human Gene Id：51455

Human Swiss Prot No：Q9UBZ9

Mouse Swiss Prot No：Q920Q2

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：REV1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：137kD

Background： This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016],

Function：domain:The C-terminal domain is necessary for protein interactions.,function:Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.,similarity:Belongs to the DNA polymerase type-Y family.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 umuC domain.,subunit:Monomer. Binds MAD2L2, POLH, POLI, POLK and REV3L. May bind ITGA3.,tissue specificity:Ubiquitous.,

Subcellular Location：Nucleus .

Expression：Ubiquitous.